Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery.

Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery.

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Genetic variants within the endothelin-1 gene (EDN1) have been associated with several cardiovascular diseases and may act as genetic prognostic markers.Here, we canadian white blenheim apricot explored the overall relevance of EDN1 polymorphisms for long-term survival in patients undergoing on-pump cardiac surgery.A prospectively collected cohort of 455 Caucasian patients who underwent cardiac surgery with cardiopulmonary bypass was followed up for 5 years.

The obtained genotypes and inferred haplotypes were analyzed for their associations with the five-year mortality rate (primary endpoint).The EDN1 T-1370G and K198N genotype distributions did not deviate from Hardy-Weinberg equilibrium and the major allele frequencies were 83% and 77%, respectively.The cardiovascular risk factors were equally distributed in terms of the different genotypes and haplotypes associated with the two polymorphisms.

The five-year mortality rate did not differ among the different EDN1 T-1370G and K198N genotypes and haplotypes.Haplotype analysis revealed that carriers of the G-T (compound EDN1 T-1370G G/K198N T) haplotype had a higher cardiac index than did non-carriers (p = 0.0008); nicabate patches however, this difference did not reach significance after adjusting for multiple testing.

The results indicate that common variations in EDN1 do not act as prognostic markers for long-term survival in patients undergoing on-pump cardiac surgery.